At the moment, There are 2 types of studies on itaconate: Irg1−/− macrophages as well as regulatory effect of itaconate derivatives. Both of these effects have been complementary and exposed the regulatory mechanisms of itaconate involved alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription aspect three (ATF3) https://nielsonk665whs8.plpwiki.com/user