Evidence-based professional reference pages authored by our clinical team for the use of medical professionals. An acute exacerbation is more commonly known birli a 'flare-up'. An acute exacerbation of chronic obstructive pulmonary disease (COPD) is a sudden worsening of COPD symptoms compared with the usual severity of symptoms. Topical steroids https://www.metooo.es/u/672d0f1bd5e0d01190f7f4a1