Background: Depression is one of the most psychiatric disorders that there are many treatments for it. Milk thistle is a plant which has many pharmacologic effects such as antioxidant. anti-inflammatory and anticancer. It is reported that silymarin (main component of milk thistle) increase the concentration of some neurotransmitter in brain. https://www.roneverhart.com/Sheepshead-Bay-Boats-2-Brooklyn-NY/